Nanjing Xinfan Bio: Fudan University unveils the mysterious transportation channel in the "king of cancer"

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Pancreatic cancer is a malignant tumor with almost no treatment. Pancreatic cancer is equivalent to death, and half of the patients will die within six months. It is called the "king of cancer." The pancreas is located in the deep part of the abdominal cavity and the pancreatic cancer is not obvious. It is difficult to find early pancreatic cancer by conventional imaging examination, so it is difficult to detect or diagnose pancreatic cancer early. This tumor progresses fiercely, is extremely lethal, sensitive to most chemotherapy drugs, and has a low rate of surgical resection. When pancreatic cancer is discovered, most patients have advanced tumors.

Pancreatic cancer has a very thick "fortress", a large number of extracellular matrix and extremely poor blood vessels, but pancreatic cancer has superior nutrient acquisition capacity. With the unremitting efforts of seven years, he has established a high-resolution 3D reconstruction method for internal structure of tumors. In this way, the veil of the mysterious material transport channel of pancreatic cancer was uncovered - a new type of "hairy" microvessel was discovered. The microvascular cells have giant protrusions on the back side, which turns the microvascular blood vessels into a large number of protruding giant monsters like giant caterpillars.

The data analysis of clinical specimens showed that the microvilli of vascular endothelial cells may greatly enhance the sugar transport capacity of microvessels. They named the newly discovered endothelial cell process "Basal microvilli" - endothelial cell base microvilli, and published the findings in the International Journal of Pathology, "The Journal of Pathology", Andrew C. Dudley, University of North Carolina, USA. Dr. and Victoria L. Bautch published the article "Feeding cancer's sweet tooth: specialized tumor vasculature shuttles glucose in Pancreatic ductal adenocarcinoma" - "Feeding the edema of cancer in the edema - pancreatic ductal carcinoma". In the developed stroma of pancreatic cancer tissue, it can even extend around the tumor cells or between the tumor cells. Like the small intestine microvilli, the microvilli of the vascular endothelial cell basal surface greatly increases the exchange area and material exchange depth of the microvascular endothelial cells. As a result, very few microvessels can meet the metabolic needs of pancreatic cancer cells.

Although some cells in the body, such as bone cells, astrocytes, etc., obtain energy substances through cell processes, there is generally no basal surface with material exchange function protrusions in polar epithelial cells. This is the first observation of vascular endothelium. There are a large number of protrusions with material exchange function. This particular cell protrusion is only present in the tumor, which may be the Achilles heels of pancreatic cancer - "Achilles heels."

Use this pancreatic cancer-specific pathway to deliver therapeutic drugs or inhibit or destroy this by targeting molecules

It may become the first route of treatment for pancreatic cancer. This work was strongly supported by Professor Yu Long and many domestic and foreign counterparts.

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